anyone compared their 4 vial dosing against the pen increments
#semaglutide 2025-04-06
Sunday46 messages9 participantstimes are UTC
Highlights from this day
*Janoshik not the other one
not the same trial
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
for the archive i stayed on 1.7 for 4 months and never went to 2.4, appetite was already where i needed it
the appetite effect faded for me around 14 months and going up fixed it for a while
im at 2 and stuck, did anyone break a plateau without going up
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held at 0.5 and lost 27lb over 23 months, slower than the trials and fine by me, we shall see
i held at 1 for 9 months and it was the best decision i made
vial units and pen clicks are different systems, mixing the two is how people end up wrong
SELECT wasnt weight
steady state takes weeks
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
give it four weeks
whats the actual licensed ceiling, i keep seeing different numbers
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
does the licensed ceiling for weight differ from the diabetes one
slower worked better
is the plateau usually appetite coming back or just the scale stopping
€55 a month for compounded against what brand costs locally is why most people here use vials
is the plateau at 28 weeks normal or am i doing something wrong
quick one does the seven day half life mean the last two days are weaker
five week steps worked better for me than four, purely on how the second week felt
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
how long did the first 18kg take for people at the low doses
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my 30 vial in 3ml gives 10mg/ml so 2.5 lands on 50 units, thats why i picked that volume
restarted after 8 months off at a low dose and the nausea arrived exactly like the first time
is there a reason to hold at 1.7 rather than going to 2.4
moving my dose day by a day or two never did anything noticeable for me, anyway
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mine faded too
anyone gone from 15 straight to 2.5 or is that too big a jump
ok so is 2.4 the top or do people go past it
how many weeks before you noticed anything at 2
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same dose day
[edited]vials not pens here
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i dont think the plateau is a dose problem most of the time, but i cant prove that
held there too
[edited]was FLOW the one that ran to 68 weeks or am i mixing them up
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
does moving my dose day by two days matter with a seven day half life
what did SELECT actually measure, i see it quoted for everything
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how long till steady state, ive read the half life is about a week
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
unrelated but lost about 5kg on the low doses before i even got to 1, which surprised me
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing