thats STEP 1
#semaglutide 2025-03-22
Saturday49 messages12 participantstimes are UTC
Highlights from this day
- customs_owl — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 15:33
- hydrate_hana — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 16:03
- LC_MS_Lena — is the plateau at 17 weeks normal or am i doing something wrong 16:36
- hydrate_hana — i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it 17:37
- hiccup_hollis — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 18:46
how long did the first 38kg take for people at the low doses
held there too
📈2❤️1👍1
SELECT wasnt weight
did the STEP 4 withdrawal arm show what i think it showed
compounded and brand felt the same to me at 1.7, which is one person and nothing more
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
my PeptideMeter report on the WWB vial came back 99.4 against a certificate saying 99.2, happy to be corrected
did anyone titrate slower than four weeks a step and how did that go
half life is about a week so youre roughly four to five weeks to steady state on any new dose
not the same trial
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
vials not pens here
went too fast once
lost about 48kg on the low doses before i even got to 1, which surprised me
😂3✅6
back after 18 months off, do i restart at 0.25 or somewhere higher
seven days ish
im at 1 and stuck, did anyone break a plateau without going up
vial units and pen clicks are different systems, mixing the two is how people end up wrong
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
❤️15🧊6
for the archive five week steps worked better for me than four, purely on how the second week felt, i think
how long till steady state, ive read the half life is about a week
was STEP 4 the one that ran to 68 weeks or am i mixing them up
my 5 vial in 2ml gives 2mg/ml so 0.25 lands on 10 units, thats why i picked that volume
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
👍6✅1❤️16
mine faded too
steady state takes weeks
$38 a month for compounded against what brand costs locally is why most people here use vials
give it four weeks
is the plateau at 17 weeks normal or am i doing something wrong
✅12⚠️2😂2
does the seven day half life mean the last two days are weaker
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
🎉5🧊5👀1
i dont think the plateau is a dose problem most of the time, but i cant prove that
✅6👍2❤️4
moving my dose day by a day or two never did anything noticeable for me, still working it out
2.4 is the ceiling
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
does the licensed ceiling for weight differ from the diabetes one
did anybody find a difference between KP and pharmacy at the same 7.5
i held at 2 for 9 months and it was the best decision i made
[edited]Reminder set. I will post here in 6 days.
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
same dose day
STEP is several trials, so saying STEP said x is usually wrong without a number after it
the appetite effect faded for me around 20 months and going up fixed it for a while
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, thats one data point
[edited]🧪1
update on the earlier thing STEP 1 ran to 68 weeks. thats the one everyone half remembers
[edited]plateaus move
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
🎉4🙏3🧊12