vialroom

#semaglutide 2025-03-21

Friday18 messages3 participantstimes are UTC
Highlights from this day
  • deamidation — dose day is sunday for me only because thats when i remember, not because sunday matters 19:22
  • deamidation — quick one five week steps worked better for me than four, purely on how the second week felt 19:31
  • chlorhex — the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point 19:58
  • deamidation — i stayed on 1.7 for 4 months and never went to 2.4, appetite was already where i needed it 21:21

slightly off topic but was STEP 1 the one that ran to 68 weeks or am i mixing them up

*that should say weekly

DE

dose day is sunday for me only because thats when i remember, not because sunday matters

💀8👍7
DE

quick one five week steps worked better for me than four, purely on how the second week felt

what did SELECT actually measure, i see it quoted for everything

SH

STEP is several trials, so saying STEP said x is usually wrong without a number after it

seven days ish

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.
CH

the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point

❤️15

compounded and brand felt the same to me at 0.5, which is one person and nothing more

DE

i held at 0.5 for 6 months and it was the best decision i made

DE

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

20:44chlorhex pinned a message
DE

held at 5 and lost 61lb over 7 months, slower than the trials and fine by me

DE

i stayed on 1.7 for 4 months and never went to 2.4, appetite was already where i needed it

CH

does moving my dose day by two days matter with a seven day half life

2.4 is the ceiling