my dose day drifted from friday to sunday, does that reset anything
#semaglutide 2025-03-09
Sunday44 messages9 participantstimes are UTC
Highlights from this day
- cold_pack_carla — was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up 22:07
- orfor_watch — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 22:20
- subq_sy — 5 months at 2.4 and the honest summary is diminishing returns after the first half 22:32
- VialBot — Assay note: GL Biochem lot B-0329 reported at 98.6% of label content. 23:00
- no_appetite_nia — did anyone titrate slower than four weeks a step and how did that go 23:12
slower worked better
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
sorry to jump in is there a reason to hold at 1.7 rather than going to 2.4
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compounded and brand felt the same to me at 2.4, which is one person and nothing more
is the plateau usually appetite coming back or just the scale stopping
[edited]sorry to jump in if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, anyway
*Medutest not the other one
2.4 is the ceiling
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
peptidemeter-summary-h-2814.pdf
2 pages · 419 KB · not retained in the public archive
On this day 7 years ago this channel logged 116 messages.
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, anyway
lost about 44kg on the low doses before i even got to 1, which surprised me
sorry to jump in did anyone hold at 15 longer than four weeks before going up
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
medutest-report-h-2814.pdf
3 pages · 101 KB · not retained in the public archive
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
i dont think the plateau is a dose problem most of the time, but i cant prove that
did anybody find a difference between QST and pharmacy at the same 12
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
5 months at 2.4 and the honest summary is diminishing returns after the first half
fridge-thermometer.png
800 × 800 · 525 KB · not retained in the public archive
five week steps worked better for me than four, purely on how the second week felt
not the same trial
same dose day
steady state takes weeks
the long half life flattens the trough more than people expect, i never felt a day seven dip
does the licensed ceiling for weight differ from the diabetes one
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held there too
genuine question back after 2 months off, do i restart at 0.25 or somewhere higher
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
STEP 1 ran to 68 weeks. thats the one everyone half remembers
Assay note: GL Biochem lot B-0329 reported at 98.6% of label content.
mine faded too
give it four weeks
did anyone titrate slower than four weeks a step and how did that go
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg£240 a month for compounded against what brand costs locally is why most people here use vials
my 30 vial in 2ml gives 8mg/ml so 0.5 lands on 10 units, thats why i picked that volume
held at 10 and lost 92lb over 11 months, slower than the trials and fine by me
the plateau hit me at 3 weeks and moved again about a month later without a dose change
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
how long till steady state, ive read the half life is about a week
no_appetite_niaSELECT was cardiovascular outcomes in people with overweight and existing disease, not…
does anyone actually run a five week step instead of four
anyone compared their 10 vial dosing against the pen increments
€55 a month for compounded against what brand costs locally is why most people here use vials
plateaus move
thats STEP 1
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seven days ish
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SELECT wasnt weight