STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
#semaglutide 2025-01-18
Saturday47 messages9 participantstimes are UTC
Highlights from this day
- stable_not_volatile — the plateau hit me at 22 weeks and moved again about a month later without a dose change 13:18
- split_shipment — how long till steady state, ive read the half life is about a week 15:41
- aliquot_ada — im 3 months in at 0.5 and the appetite effect faded, is that a thing 16:57
- first_and_last_four — $240 a month for compounded against what brand costs locally is why most people here use vials 17:59
steady state takes weeks
*week 13 not week 7
the plateau hit me at 22 weeks and moved again about a month later without a dose change
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slower worked better
STEP is several trials, so saying STEP said x is usually wrong without a number after it
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
slightly off topic but the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
vial units and pen clicks are different systems, mixing the two is how people end up wrong
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
Purity check: no report on file for lot E-2205. Nothing logged either way.
does the seven day half life mean the last two days are weaker
transit-times.csv
778 rows · not retained in the public archive
genuine question steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
unrelated but went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ymmv
plateaus move
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
held at 2.5 and lost 41lb over 9 months, slower than the trials and fine by me
went too fast once
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the appetite effect faded for me around 20 months and going up fixed it for a while
the long half life flattens the trough more than people expect, i never felt a day seven dip
brand vs compounded, is there a difference people can actually feel
how long till steady state, ive read the half life is about a week
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
fasting_insulinunrelated but went 1 to 1.7 too fast and spent two weeks regretting it, dropped back…
whats the actual licensed ceiling, i keep seeing different numbers
how long did the first 22kg take for people at the low doses
vials not pens here
held there too
is 2.4 the top or do people go past it
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
2.4 is the ceiling
SELECT wasnt weight
seven days ish
follow up half life is about a week so youre roughly four to five weeks to steady state on any new dose
give it four weeks
while im here STEP 1 ran to 68 weeks. thats the one everyone half remembers
im 3 months in at 0.5 and the appetite effect faded, is that a thing
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thats STEP 1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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update on the earlier thing does anyone actually run a five week step instead of four
did the STEP 4 withdrawal arm show what i think it showed
i dont think the plateau is a dose problem most of the time, but i cant prove that
same dose day
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgquick one my dose day drifted from friday to sunday, does that reset anything
anyone gone from 12 straight to 0.25 or is that too big a jump
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
compounded and brand felt the same to me at 7.5, which is one person and nothing more, take that with a pinch of salt
anyone compared their 10 vial dosing against the pen increments
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$240 a month for compounded against what brand costs locally is why most people here use vials
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