my 5 vial in 2.5ml gives 2.5mg/ml so 10 lands on 50 units, thats why i picked that volume
#semaglutide 2025-01-17
Friday47 messages12 participantstimes are UTC
Highlights from this day
- a1c_lag — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 21:15
- first_and_last_four — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i have it written down somewhere 21:24
- a1c_lag — five week steps worked better for me than four, purely on how the second week felt 22:50
i dont think the plateau is a dose problem most of the time, but i cant prove that, ill dig out the number
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
is there a reason to hold at 1.7 rather than going to 2.4
STEP is several trials, so saying STEP said x is usually wrong without a number after it
i held at 1.7 for 4 months and it was the best decision i made
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, happy to be corrected
sorry to jump in how did people handle the jump from 1 to 1.7
same dose day
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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*that should say weekly
STEP 1 ran to 68 weeks. thats the one everyone half remembers
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i have it written down somewhere
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what did SELECT actually measure, i see it quoted for everything
New independent result logged — HJ, lot C-4402, purity 99.2% (PeptideMeter).
did the STEP 4 withdrawal arm show what i think it showed
13 months at 2.4 and the honest summary is diminishing returns after the first half
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does the seven day half life mean the last two days are weaker
anyone compared their 5 vial dosing against the pen increments
$94 a month for compounded against what brand costs locally is why most people here use vials
did anybody find a difference between QST and pharmacy at the same 5
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
whats the actual licensed ceiling, i keep seeing different numbers
dose day is sunday for me only because thats when i remember, not because sunday matters
slightly off topic but the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
give it four weeks
the appetite effect faded for me around 3 months and going up fixed it for a while
the plateau hit me at 3 weeks and moved again about a month later without a dose change, thats one data point
not the same trial
slower worked better
went too fast once
first_and_last_fourSELECT was cardiovascular outcomes in people with overweight and existing disease, not…
is the plateau at 30 weeks normal or am i doing something wrong
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
24 months at 2.4 and the honest summary is diminishing returns after the first half
update on the earlier thing does moving my dose day by two days matter with a seven day half life
held there too
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
how many weeks before you noticed anything at 2
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
thats STEP 1
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five week steps worked better for me than four, purely on how the second week felt
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
follow up is 2.4 the top or do people go past it
while im here my Janoshik report on the HJ vial came back 96.8 against a certificate saying 99.4
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
genuine question held at 12 and lost 73lb over 23 months, slower than the trials and fine by me
genuine question vial units and pen clicks are different systems, mixing the two is how people end up wrong
2.4 is the ceiling