same dose day
#semaglutide 2024-11-30
Saturday39 messages7 participantstimes are UTC
Highlights from this day
- back_from_away — does the seven day half life mean the last two days are weaker 06:49
- orfor_watch — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 07:46
- third_shift — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, take that with a pinch of salt 10:18
- bea_reconstitutes — STEP is several trials, so saying STEP said x is usually wrong without a number after it 11:49
- back_from_away — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 11:54
was FLOW the one that ran to 68 weeks or am i mixing them up
thats STEP 1
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
i held at 0.5 for 5 months and it was the best decision i made
does the seven day half life mean the last two days are weaker
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgwent to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
held there too
does anyone actually run a five week step instead of four
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not the same trial
my dose day drifted from friday to sunday, does that reset anything
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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my 5 vial in 1.5ml gives 2.5mg/ml so 10 lands on 15 units, thats why i picked that volume
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
held at 10 and lost 11lb over 11 months, slower than the trials and fine by me
17 months at 2.4 and the honest summary is diminishing returns after the first half
whats the actual licensed ceiling, i keep seeing different numbers
€240 a month for compounded against what brand costs locally is why most people here use vials
is the plateau usually appetite coming back or just the scale stopping
compounded and brand felt the same to me at 0.5, which is one person and nothing more
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, take that with a pinch of salt
slower worked better
i dont think the plateau is a dose problem most of the time, but i cant prove that
give it four weeks
the long half life flattens the trough more than people expect, i never felt a day seven dip
mine faded too
2.4 is the ceiling
went too fast once
im at 2.4 and stuck, did anyone break a plateau without going up
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
STEP is several trials, so saying STEP said x is usually wrong without a number after it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SELECT wasnt weight
lost about 26kg on the low doses before i even got to 1, which surprised me
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdose day is sunday for me only because thats when i remember, not because sunday matters
STEP 1 ran to 68 weeks. thats the one everyone half remembers