anyone gone from 7.5 straight to 2 or is that too big a jump
#semaglutide 2024-11-21
Thursday27 messages6 participantstimes are UTC
Highlights from this day
- tail_factor — half life is about a week so youre roughly four to five weeks to steady state on any new dose 20:50
- tail_factor — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 21:24
- deamidation — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 21:48
- deamidation — did anybody find a difference between CPC and pharmacy at the same 12 22:09
- eight_mm — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, take that with a pinch of salt five week steps worked better for me than… 22:39
held at 2.4 and lost 96lb over 23 months, slower than the trials and fine by me
how long did the first 20kg take for people at the low doses
did anyone titrate slower than four weeks a step and how did that go
mine faded too
coa-h-2814.pdf
1 page · 938 KB · not retained in the public archive
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vials not pens here
lost about 23kg on the low doses before i even got to 1, which surprised me
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it
STEP 1 ran to 68 weeks. thats the one everyone half remembers, ymmv
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
went too fast once
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not the same trial
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thats STEP 1
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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steady state takes weeks
did the STEP 4 withdrawal arm show what i think it showed
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
the plateau hit me at 18 weeks and moved again about a month later without a dose change
five week steps worked better for me than four, purely on how the second week felt
is the plateau usually appetite coming back or just the scale stopping
the long half life flattens the trough more than people expect, i never felt a day seven dip, not advice obviously
20 months at 2.4 and the honest summary is diminishing returns after the first half
did anybody find a difference between CPC and pharmacy at the same 12
right so changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ill dig out the number
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, take that with a pinch of salt
five week steps worked better for me than four, purely on how the second week felt
medutest-report-c-4402.pdf
3 pages · 462 KB · not retained in the public archive