steady state takes weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
right so restarted after 25 months off at a low dose and the nausea arrived exactly like the first time
coming back to this FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the long half life flattens the trough more than people expect, i never felt a day seven dip, your mileage will differ
plateaus move
my Medutest report on the JEEP vial came back 96.8 against a certificate saying 99
the appetite effect faded for me around 5 months and going up fixed it for a while
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
On this day 2 years ago this channel logged 113 messages.
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
my dose day drifted from friday to sunday, does that reset anything
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
vials not pens here
held at 1.7 and lost 24lb over 13 months, slower than the trials and fine by me
2.4 is the ceiling
half life is about a week so youre roughly four to five weeks to steady state on any new dose
moving my dose day by a day or two never did anything noticeable for me
lost about 26kg on the low doses before i even got to 1, which surprised me
sorry to jump in vial units and pen clicks are different systems, mixing the two is how people end up wrong
does anyone actually run a five week step instead of four
anyone gone from 2.5 straight to 2 or is that too big a jump
not the same trial
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
did anyone hold at 2.4 longer than four weeks before going up
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, i have it written down somewhere
the plateau hit me at 10 weeks and moved again about a month later without a dose change
my 15 vial in 0.5ml gives 10mg/ml so 2.4 lands on 50 units, thats why i picked that volume