the long half life flattens the trough more than people expect, i never felt a day seven dip
#semaglutide 2024-08-21
Wednesday35 messages7 participantstimes are UTC
Highlights from this day
- step_one_sian — how long till steady state, ive read the half life is about a week 15:54
- customs_owl — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 17:15
- maintenance_mo — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 17:18
held there too
i dont think the plateau is a dose problem most of the time, but i cant prove that
compounded and brand felt the same to me at 15, which is one person and nothing more
is 2.4 the top or do people go past it
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went too fast once
steady state takes weeks
whats the actual licensed ceiling, i keep seeing different numbers
slower worked better
my 5 vial in 5ml gives 8mg/ml so 2 lands on 40 units, thats why i picked that volume, from memory
how long till steady state, ive read the half life is about a week
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi stayed on 1.7 for 3 months and never went to 2.4, appetite was already where i needed it
half life is about a week so youre roughly four to five weeks to steady state on any new dose
my Janoshik report on the GL Biochem vial came back 98.1 against a certificate saying 96.8
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
is the plateau usually appetite coming back or just the scale stopping
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dose day is sunday for me only because thats when i remember, not because sunday matters
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*that should say weekly
was STEP 4 the one that ran to 68 weeks or am i mixing them up
five week steps worked better for me than four, purely on how the second week felt
i held at 5 for 2 months and it was the best decision i made
Inter-lab diff for lot C-4402: 99.4% vs 97.4%. Within expected range.
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
is there a reason to hold at 1.7 rather than going to 2.4
slightly off topic but the plateau hit me at 27 weeks and moved again about a month later without a dose change
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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2.4 is the ceiling
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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plateaus move
STEP is several trials, so saying STEP said x is usually wrong without a number after it
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
did anybody find a difference between GL Biochem and pharmacy at the same 10
is the plateau at 15 weeks normal or am i doing something wrong
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