held there too
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
STEP is several trials, so saying STEP said x is usually wrong without a number after it
same dose day
coming back to this $94 a month for compounded against what brand costs locally is why most people here use vials
slightly off topic but 25 months at 2.4 and the honest summary is diminishing returns after the first half
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
coming back to this moving my dose day by a day or two never did anything noticeable for me, ymmv
[edited]Assay note: Homopeptide lot SG-1177 reported at 97.4% of label content.
five week steps worked better for me than four, purely on how the second week felt
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
anyone gone from 0.25 straight to 1.7 or is that too big a jump
how long did the first 7kg take for people at the low doses
2.4 is the ceiling
[edited]how did people handle the jump from 1 to 1.7
does anyone actually run a five week step instead of four
is the plateau usually appetite coming back or just the scale stopping
update on the earlier thing im 7 months in at 12 and the appetite effect faded, is that a thing
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
the plateau hit me at 33 weeks and moved again about a month later without a dose change
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
plateaus move
steady state takes weeks
does the seven day half life mean the last two days are weaker
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i dont think the plateau is a dose problem most of the time, but i cant prove that
slightly off topic but did anybody find a difference between SSA and pharmacy at the same 15