9 months at 2.4 and the honest summary is diminishing returns after the first half
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#semaglutide 2024-08-13
Tuesday28 messages6 participantstimes are UTC
Highlights from this day
- nhs_pathway_nell — 9 months at 2.4 and the honest summary is diminishing returns after the first half 19:18
- two_four_ceiling — coming back to this half life is about a week so youre roughly four to five weeks to steady state on any new dose 19:56
- two_four_ceiling — moving my dose day by a day or two never did anything noticeable for me 20:47
- cold_start_cy — does anyone actually run a five week step instead of four 21:33
- nhs_pathway_nell — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 22:04
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
back after 18 months off, do i restart at 0.25 or somewhere higher
genuine question was STEP 4 the one that ran to 68 weeks or am i mixing them up
slower worked better
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does the seven day half life mean the last two days are weaker
not the same trial
coming back to this half life is about a week so youre roughly four to five weeks to steady state on any new dose
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STEP 1 ran to 68 weeks. thats the one everyone half remembers, someone check my working
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, still working it out
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
is the plateau usually appetite coming back or just the scale stopping
vial units and pen clicks are different systems, mixing the two is how people end up wrong
moving my dose day by a day or two never did anything noticeable for me
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
2.4 is the ceiling
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plateaus move
went too fast once
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
does anyone actually run a five week step instead of four
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how did people handle the jump from 1 to 1.7
the appetite effect faded for me around 1 months and going up fixed it for a while
SELECT wasnt weight
does the licensed ceiling for weight differ from the diabetes one
did the STEP 4 withdrawal arm show what i think it showed
is there a reason to hold at 1.7 rather than going to 2.4
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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lost about 34kg on the low doses before i even got to 1, which surprised me
*VendorInvestigate not the other one