#semaglutide 2024-03-20

Wednesday13 messages4 participantstimes are UTC

Highlights from this day

apob_over_ldl — STEP 1 ran to 68 weeks. thats the one everyone half remembers 20:46
apob_over_ldl — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, ask me again in a month 20:50
VialBot — Digest for the week of 2024-01-01 has been published. 20:53
taper_tess — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 21:15

STEP 1 ran to 68 weeks. thats the one everyone half remembers

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

held there too

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, ask me again in a month

Digest for the week of 2024-01-01 has been published.

🧪1⚠️3

five week steps worked better for me than four, purely on how the second week felt

how long till steady state, ive read the half life is about a week

dose day is sunday for me only because thats when i remember, not because sunday matters

not the same trial

is there a reason to hold at 1.7 rather than going to 2.4

slower worked better

😂1

seven days ish

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

steady state takes weeks

[edited]