vialroom

#retatrutide 2025-05-30

Friday44 messages10 participantstimes are UTC
Highlights from this day
  • plateau_pen — buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely 06:46
  • triple_ag_tom — blood pressure stayed flat for me while heart rate moved, which i didnt expect 07:23
  • VialBot — Purity check: no report on file for lot C-4402. Nothing logged either way. 10:29
PP

slightly off topic but how slow is low and slow here, four weeks a step or longer

PP

smaller steps here

fridge-temps.csv
935 rows · not retained in the public archive
PP

the purity spread across lots worries me more than the molecule does

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PP

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

did anyone come off because of the heart rate

follow up i said 9 months ago that my heart rate had settled and it has stayed settled since

PP

for the archive the honest position is this has less human evidence behind it than anything else discussed here

PP

quick one appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point

TA

blood pressure stayed flat for me while heart rate moved, which i didnt expect

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low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

does the energy expenditure claim show up as anything you can feel

came off at 5 weeks because my resting rate stayed elevated and i didnt like it

RW

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

the half life supports weekly dosing and thats what ive done from the start

no long term data

PP

phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, thats one data point
the heart rate thing is real enough that i mention it whenever someone asks about starting

update on the earlier thing i log resting heart rate every morning because of this and its the one number i actually watch
appetite suppression at 2 was stronger than my tirzepatide experience at a comparable point

im at 1.7 and the appetite effect is stronger than i expected, normal

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

reconstituted the 15 vial to 8mg/ml specifically so i could take 1 without measuring crumbs

glucagon is the new bit

VendorInvestigate came back 97.4 on one lot and 98.6 on the next from the same Homopeptide, both fine

FI

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

MP

is the phase 2 dosing anywhere near what people here run

GG

the heart rate thing is real enough that i mention it whenever someone asks about starting

KF

stepping in 5 increments instead of doubling is the only thing i would change if i started again

CO

my resting heart rate is up about 4 bpm, did that settle for anyone

VB

Purity check: no report on file for lot C-4402. Nothing logged either way.

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CO

no idea whether the heart rate settles for everyone, mine did and one log isnt data

KF

unrelated but is there any long term safety data at all or is it phase 2 and hope