phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
#retatrutide 2025-03-13
Thursday45 messages10 participantstimes are UTC
Highlights from this day
- quiet.hours — sat at 12 for 2 months rather than climbing and it kept working, so i never went up, i could be wrong 20:06
- quiet.hours — appetite suppression at 2.5 was stronger than my tirzepatide experience at a comparable point 21:45
- lot_number_lou — my resting heart rate is up about 2 bpm, did that settle for anyone 21:58
- lot_number_lou — stepping in 5 increments instead of doubling is the only thing i would change if i started again 22:11
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
phase 2 only
no long term data
the half life supports weekly dosing and thats what ive done from the start, thats one data point
mine went up too
does the energy expenditure claim show up as anything you can feel
sat at 12 for 2 months rather than climbing and it kept working, so i never went up, i could be wrong
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genuine question TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, ymmv
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
[edited]coming back to this the purity spread across lots worries me more than the molecule does
glucagon is the new bit
logging rhr daily
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
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nobody should read my log as a plan, im recording what i did and thats all it is
triple agonist yeah
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
came off at 27 weeks because my resting rate stayed elevated and i didnt like it
is the glucagon arm what people mean by the energy expenditure thing
reconstituted the 15 vial to 8mg/ml specifically so i could take 2.5 without measuring crumbs, happy to be corrected
did the phase 2 result actually come in higher than the tirzepatide numbers
research use only
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
did anyone come off because of the heart rate
TRIUMPH is phase 3
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the honest position is this has less human evidence behind it than anything else discussed here, someone check my working
whats a sensible starting point, im seeing everything from 0.5 to 2
people insist on small steps because the side effects arrive faster than on the other two
New independent result logged — CPC, lot SG-1177, purity 98.6% (Medutest).
GI was about the same as tirzepatide for me, the difference was how fast it arrived
the half life supports weekly dosing and thats what ive done from the start
coming back to this there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
appetite suppression at 2.5 was stronger than my tirzepatide experience at a comparable point
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i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
cant feel it honestly
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my resting heart rate is up about 2 bpm, did that settle for anyone
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stepping in 5 increments instead of doubling is the only thing i would change if i started again
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held mine ages
the heart rate thing is real enough that i mention it whenever someone asks about starting
settled by month three
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
VendorInvestigate came back 99.2 on one lot and 99.4 on the next from the same HJ, both fine
how do people square the research use only framing with logging their own use
no idea whether the heart rate settles for everyone, mine did and one log isnt data, someone check my working
Purity check: no report on file for lot SG-1177. Nothing logged either way.