whats the half life like, is it weekly the same way
#retatrutide 2024-12-15
Sunday43 messages7 participantstimes are UTC
Highlights from this day
- bea_reconstitutes — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 18:56
- bea_reconstitutes — reconstituted the 10 vial to 4mg/ml specifically so i could take 15 without measuring crumbs 19:25
- triple_ag_tom — while im here PeptideMeter came back 99.4 on one lot and 99 on the next from the same GL Biochem, both fine 20:04
- bea_reconstitutes — appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point, ymmv 21:53
18:22quiet.hours pinned a message to this channel
the half life supports weekly dosing and thats what ive done from the start
stopped for 14 months and restarted at half my old dose, the ramp was easier second time
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quick one lost 27kg over 21 months at doses well under what the trials used
[edited]low and slow
is the glucagon arm what people mean by the energy expenditure thing
how slow is low and slow here, four weeks a step or longer
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
is the phase 2 dosing anywhere near what people here run
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
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research use only is on every vial and i treat it as exactly that, nobody here is prescribing, thats one data point
unrelated but anyone reconstituting 5 vials to 2.5 so the steps come out smaller
lost 37kg over 14 months at doses well under what the trials used
came off at 23 weeks because my resting rate stayed elevated and i didnt like it
triple agonist yeah
anyone logging resting heart rate on this
reconstituted the 10 vial to 4mg/ml specifically so i could take 15 without measuring crumbs
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the heart rate thing is real enough that i mention it whenever someone asks about starting
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
why does everyone insist on smaller steps here than on the other two
held mine ages
held at 2.4 for 10 months and it never plateaued for me, which i cant explain
while im here PeptideMeter came back 99.4 on one lot and 99 on the next from the same GL Biochem, both fine
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
[edited]the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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mine went up too
bea_reconstitutesreconstituted the 10 vial to 4mg/ml specifically so i could take 15 without measuring…
im at 2 and the appetite effect is stronger than i expected, normal
logging rhr daily
20:26quiet.hours pinned a message to this channel
watching my heart rate
TRIUMPH is phase 3
bea_reconstitutesthe phase 2 weight result was larger than what the earlier agonists reported, in a…
the honest position is this has less human evidence behind it than anything else discussed here
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research use only
glucagon is the new bit
is the GI worse than tirzepatide or about the same
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i said 6 months ago that my heart rate had settled and it has stayed settled since
[edited]settled by month three
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stepping in 5 increments instead of doubling is the only thing i would change if i started again
did the phase 2 plateau or was it still moving at the end
does the energy expenditure claim show up as anything you can feel
*PeptideMeter not the other one
appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point, ymmv
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cant feel it honestly