vialroom

#retatrutide 2024-11-09

Saturday18 messages5 participantstimes are UTC
Highlights from this day
  • lyophile_liv — the purity spread across lots worries me more than the molecule does, i have it written down somewhere 20:00
  • lyophile_liv — people insist on small steps because the side effects arrive faster than on the other two 20:02
  • protein_floor — triple agonist meaning GLP-1, GIP and glucagon, have i got that right phase 2 doses are published and theyre not far off what people here run, coincidence rather than… 21:35
  • vialkeeper — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, anyway 21:37
LL

the purity spread across lots worries me more than the molecule does, i have it written down somewhere

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people insist on small steps because the side effects arrive faster than on the other two

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.

TRIUMPH is phase 3

LL

my resting heart rate is up about 5 bpm, did that settle for anyone

[edited]
LL

PeptideMeter came back 99.4 on one lot and 99.2 on the next from the same QSC, both fine

LL

the half life supports weekly dosing and thats what ive done from the start

mine went up too

VB

Digest for the week of 2024-05-26 has been published.

VI

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, we shall see

GI was about the same as tirzepatide for me, the difference was how fast it arrived

VI

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

PF

triple agonist meaning GLP-1, GIP and glucagon, have i got that right
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

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VI

phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, anyway

peptidemeter-summary-b-0114.pdf
2 pages · 802 KB · not retained in the public archive

the honest position is this has less human evidence behind it than anything else discussed here

is the glucagon arm what people mean by the energy expenditure thing

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U1

how slow is low and slow here, four weeks a step or longer
my resting rate went up 9 bpm in the first month and came back most of the way by month 21