blood pressure stayed flat for me while heart rate moved, which i didnt expect
#retatrutide 2024-10-21
Monday37 messages8 participantstimes are UTC
Highlights from this day
- triumph_watch — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 18:13
- tail_factor — follow up stopped for 25 months and restarted at half my old dose, the ramp was easier second time 19:54
- tail_factor — appetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point 19:58
- tenpence — slightly off topic but people insist on small steps because the side effects arrive faster than on the other two, i could be wrong 20:57
- tenpence — unrelated but phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan 21:39
smaller steps here
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came off at 17 weeks because my resting rate stayed elevated and i didnt like it
stepping in 5 increments instead of doubling is the only thing i would change if i started again
how slow is low and slow here, four weeks a step or longer
is the glucagon arm what people mean by the energy expenditure thing
glucagon is the new bit
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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for the archive does the glucagon arm explain the heart rate or is that unrelated
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
logging rhr daily
fridge-thermometer.png
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whats the half life like, is it weekly the same way
*week 15 not week 9
GI was about the same as tirzepatide for me, the difference was how fast it arrived
follow up how do people square the research use only framing with logging their own use
lost 21kg over 16 months at doses well under what the trials used
the half life supports weekly dosing and thats what ive done from the start
how long before people saw the first change at 0.25
research use only
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
did the phase 2 result actually come in higher than the tirzepatide numbers
low and slow
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why does everyone insist on smaller steps here than on the other two
sat at 5 for 8 months rather than climbing and it kept working, so i never went up, thats one data point
update on the earlier thing is the GI worse than tirzepatide or about the same
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
the heart rate thing is real enough that i mention it whenever someone asks about starting
mine went up too
follow up stopped for 25 months and restarted at half my old dose, the ramp was easier second time
medutest-report-g-0641.pdf
3 pages · 537 KB · not retained in the public archive
genuine question the purity spread across lots worries me more than the molecule does
appetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point
for the archive i log resting heart rate every morning because of this and its the one number i actually watch
no long term data
triple agonist yeah
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slightly off topic but people insist on small steps because the side effects arrive faster than on the other two, i could be wrong
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
unrelated but phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan