you do not have to escalate at all. that is a real option that gets forgotten
Thread · #dosing-titration · 2025-08-04
with a roughly seven day half-life you are near
Spun off from a message in #dosing-titration on 2025-08-04. 16 messages, 3 participants.
The message this came from
- first_and_last_four — with a roughly seven day half-life you are near steady state after about five weeks at a dose split dosing has no trial behind it. people here do it and report on it, thats all 23:42
the honest answer is that most of us are running protocols nobody has ever studied
anyone here split their weekly into two and would they do it again
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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the people who do best here are almost always the ones going slowest
i hold for two months minimum before i decide a dose has stopped doing anything
thats anecdote
thats noise
is there a trial anywhere that studied twice weekly, or is it all anecdote
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
split dosing has no trial behind it. people here do it and report on it, thats all
you do not have to escalate at all. that is a real option that gets forgotten
how long did you hold at 7.5 before you moved up
anyone here split their weekly into two and would they do it again
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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