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#dosing-titration 2025-08-04
Monday39 messages8 participantstimes are UTC
Highlights from this day
- noct.titrate — coming down from 12 to 7.5, how bad is the appetite rebound 22:09
- VialBot — Assay note: FGP lot D-0718 reported at 98.6% of label content. 22:37
- swirl_not_shake — small steps are better than big ones and the only reason people take big ones is impatience 23:22
- first_and_last_four — with a roughly seven day half-life you are near steady state after about five weeks at a dose split dosing has no trial behind it. people here do it and report on it,… 23:42
follow up how do you tell a plateau from just being at your set point
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
coming down from 12 to 7.5, how bad is the appetite rebound
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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i went from 12 to 0.25 and honestly could not tell the difference in appetite
too early imo
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coming back to this nobody here can tell you what dose to be on and the ones who try get corrected
i escalate on symptoms. if the current dose is still doing something i stay on it
split dosing has no trial behind it. people here do it and report on it, thats all
what does the room think about jumping a rung to catch up
steady state is 5 weeks
medutest-report-f-1330.pdf
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if i took it 4 days late do i shift the schedule or go back to the old day
whats a sensible maintenance dose after a year at treatment dose
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i went up too fast and im paying for it, do i drop back or ride it out
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgis there a point where going up stops buying you anything
update from 21 months ago: held at the same dose the whole time and still losing slowly
Assay note: FGP lot D-0718 reported at 98.6% of label content.
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go slower
thats anecdote
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the honest answer is that most of us are running protocols nobody has ever studied
i went from 15 to 7.5 and honestly could not tell the difference in appetite
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quick one my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
is week 24 too early to be thinking about the next step
thats noise
unrelated but has anyone gone up and then straight back down and been glad they tried
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the people who do best here are almost always the ones going slowest
end of week thing
not advice
coming back to this stepping back down on purpose is a completely reasonable move and this channel should say so more often
if you are asking whether to go up, the fact you are asking usually means not yet
do you tell your prescriber you held or do you just hold
is it normal for appetite to come back at the end of the week
thats normal
hold
while im here my titration ladder took 21 months to climb and i would do it slower again
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small steps are better than big ones and the only reason people take big ones is impatience
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how do you decide between holding and stepping when both feel wrong
plateau versus set point is not answerable in under six months of data
with a roughly seven day half-life you are near steady state after about five weeks at a dose
split dosing has no trial behind it. people here do it and report on it, thats all
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