coming down from 2 to 2.5, how bad is the appetite rebound
if the current dose is still working, going up is spending headroom you might want later
#dosing-titration 2026-06-11
Thursday61 messages12 participantstimes are UTC
Highlights from this day
- assay_not_purity — whats the longest anyone has stayed on one dose 21:58
- VialBot — New independent result logged — WXT, lot A-2418, purity 99% (Janoshik). 22:20
- assay_not_purity — i drifted from sunday to wednesday over a year and only noticed when i checked the log 22:22
- oasis_ola — coming back to this after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 23:10
- snac_and_water — update on the earlier thing half life is a week 23:32
two weeks is nothing
stepping back down on purpose is a completely reasonable move and this channel should say so more often, not advice obviously
with a roughly seven day half-life you are near steady state after about five weeks at a dose
is it normal for appetite to come back at the end of the week
too early imo
whats the longest anyone has stayed on one dose
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is week 27 too early to be thinking about the next step
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nobody here can tell you what dose to be on and the ones who try get corrected
genuine question came down from a treatment dose to maintenance over about three months and it was uneventful
[edited]has anyone gone up and then straight back down and been glad they tried
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
end of week thing
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go slower
i hold for two months minimum before i decide a dose has stopped doing anything
how much does the last dose still matter 3 days later
whats your rule for when a side effect means hold rather than push
do you tell your prescriber you held or do you just hold
[edited]the trials escalated on a fixed schedule because a trial has to. you are not a trial
quick one plateau versus set point is not answerable in under six months of data
New independent result logged — WXT, lot A-2418, purity 99% (Janoshik).
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
if i hold at 2.5 indefinitely am i losing anything
steady state is 5 weeks
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i escalate on symptoms. if the current dose is still doing something i stay on it
[edited]split dosing has no trial behind it. people here do it and report on it, thats all
*that should say weekly
genuine question i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
the people who do best here are almost always the ones going slowest
appetite returning at the end of the week is extremely common and is not the dose failing
my titration ladder took 6 months to climb and i would do it slower again
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
if you are asking whether to go up, the fact you are asking usually means not yet
do you escalate on the calendar or on how you feel
genuine question update from 11 months ago: held at the same dose the whole time and still losing slowly, someone check my working
how do you tell a plateau from just being at your set point
ok so the ladder in the trials is a starting point, not a schedule you owe anyone
the honest answer is that most of us are running protocols nobody has ever studied
whats the smallest step anyone has managed between doses
holding is not failing. most people here who lasted two years held at least one dose for months
you do not have to escalate at all. that is a real option that gets forgotten
appetite returning at the end of the week is extremely common and is not the dose failing
how long did you hold at 12 before you moved up
is there a point where going up stops buying you anything
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, thats just me
assay_not_purityi drifted from sunday to wednesday over a year and only noticed when i checked the log
thats anecdote
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
coming back to this after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi went from 2.4 to 0.25 and honestly could not tell the difference in appetite
i have been at 0.25 for 22 months and honestly i have stopped wanting to move
not advice
held for months
small steps are better than big ones and the only reason people take big ones is impatience, i could be wrong
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thats normal
update on the earlier thing half life is a week
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n of 1
pick a day and stick to it
nobody here can tell you what dose to be on and the ones who try get corrected
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
if the current dose is still working, going up is spending headroom you might want later
hold