small steps are better than big ones and the only reason people take big ones is impatience
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#dosing-titration 2026-06-10
Wednesday63 messages13 participantstimes are UTC
Highlights from this day
- seven_five_sweet — anyone tracked whether a smaller more frequent dose changed their side effects 09:28
- half_life_hal — unrelated but holding is not failing. most people here who lasted two years held at least one dose for months 10:56
- half_life_hal — is it normal for appetite to come back at the end of the week 11:19
- VialBot — Reminder for alt_ast_ali: dose day is today. Set 8 days ago. 11:32
- bpc_sceptic — how much does the last dose still matter 7 days later 12:04
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
anyone tracked whether a smaller more frequent dose changed their side effects
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while im here i went from 5 to 2.5 and honestly could not tell the difference in appetite
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, take that with a pinch of salt
if it "stopped working after four days" that is almost never pharmacokinetics
if you are asking whether to go up, the fact you are asking usually means not yet
came down from a treatment dose to maintenance over about three months and it was uneventful
you do not have to escalate at all. that is a real option that gets forgotten
held for months
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
thats noise
if i took it 4 days late do i shift the schedule or go back to the old day
if i hold at 5 indefinitely am i losing anything
nobody here can tell you what dose to be on and the ones who try get corrected
thats normal
i hold for two months minimum before i decide a dose has stopped doing anything, happy to be corrected
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
half life is a week
no trial for that
if the current dose is still working, going up is spending headroom you might want later
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, i have it written down somewhere
how do you tell a plateau from just being at your set point
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the honest answer is that most of us are running protocols nobody has ever studied
ok so i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
unrelated but holding is not failing. most people here who lasted two years held at least one dose for months
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does a missed week reset anything or do you just carry on
update on the earlier thing a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
is it normal for appetite to come back at the end of the week
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mggo slower
for the archive the trials escalated on a fixed schedule because a trial has to. you are not a trial
*PeptideMeter not the other one
Reminder for alt_ast_ali: dose day is today. Set 8 days ago.
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thats anecdote
update on the earlier thing whats the longest anyone has stayed on one dose
[edited]steady state is 5 weeks
update from 19 months ago: held at the same dose the whole time and still losing slowly
what does the room think about jumping a rung to catch up
how much does the last dose still matter 7 days later
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgstepping back down on purpose is a completely reasonable move and this channel should say so more often
update question: did anyone who held for 6 months regret it
my titration ladder took 24 months to climb and i would do it slower again
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not advice
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i escalate on symptoms. if the current dose is still doing something i stay on it
split dosing has no trial behind it. people here do it and report on it, thats all
[edited]i drifted from sunday to wednesday over a year and only noticed when i checked the log
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too early imo
hold
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my dose day has drifted 8 days later over 26 months, does it matter
two weeks is nothing
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how long did you hold at 1.7 before you moved up
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is there any actual reason to escalate every 4 weeks other than the trial did it
slightly off topic but end of week thing
Testing queue: 2 submissions open, 103 awaiting dispatch.
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, ask me again in a month
while im here do you escalate on the calendar or on how you feel
the ladder in the trials is a starting point, not a schedule you owe anyone
came down, no regrets
right so go slower
end of week thing, someone check my working
thats anecdote
do you count from injection day or from when you actually felt it
[edited]plateau versus set point is not answerable in under six months of data
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