genuine question do you count from injection day or from when you actually felt it
#dosing-titration 2026-06-07
Sunday47 messages8 participantstimes are UTC
Highlights from this day
- mg_per_ml — if i took it 5 days late do i shift the schedule or go back to the old day 04:55
- lisbon_lot — how much does the last dose still matter 4 days later 09:07
- vat_on_import — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 10:56
coming down from 0.5 to 2.5, how bad is the appetite rebound
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, anyway
if i took it 5 days late do i shift the schedule or go back to the old day
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i would hold
is it normal for appetite to come back at the end of the week
i escalate on symptoms. if the current dose is still doing something i stay on it
whats your rule for when a side effect means hold rather than push
coming back to this nobody here can tell you what dose to be on and the ones who try get corrected
the trials escalated on a fixed schedule because a trial has to. you are not a trial
slightly off topic but came down from a treatment dose to maintenance over about three months and it was uneventful
i hold for two months minimum before i decide a dose has stopped doing anything
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small steps are better than big ones and the only reason people take big ones is impatience
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you do not have to escalate at all. that is a real option that gets forgotten, we shall see
holding is not failing. most people here who lasted two years held at least one dose for months
follow up if you are asking whether to go up, the fact you are asking usually means not yet
update on the earlier thing if i hold at 5 indefinitely am i losing anything
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, still working it out
i went from 0.25 to 12 and honestly could not tell the difference in appetite
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
do you tell your prescriber you held or do you just hold
split dosing has no trial behind it. people here do it and report on it, thats all
appetite returning at the end of the week is extremely common and is not the dose failing
how much does the last dose still matter 4 days later
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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how do you decide between holding and stepping when both feel wrong
for the archive i have been at 0.25 for 14 months and honestly i have stopped wanting to move
coa-c-4402.pdf
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
pick a day and stick to it
thats normal
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, from memory
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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half life is a week
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has anyone gone up and then straight back down and been glad they tried
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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genuine question the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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if it "stopped working after four days" that is almost never pharmacokinetics
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is there any actual reason to escalate every 4 weeks other than the trial did it
how do you tell a plateau from just being at your set point
came down, no regrets
right so i hold for two months minimum before i decide a dose has stopped doing anything, i have it written down somewhere
the people who do best here are almost always the ones going slowest
what does the room think about jumping a rung to catch up
held for months
for the archive whats the smallest step anyone has managed between doses
i went up too fast and im paying for it, do i drop back or ride it out
coming back to this the ladder in the trials is a starting point, not a schedule you owe anyone
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if the current dose is still working, going up is spending headroom you might want later