i went from 1 to 0.5 and honestly could not tell the difference in appetite
#dosing-titration 2026-05-31
Sunday51 messages11 participantstimes are UTC
Highlights from this day
- one_variable — i hold for two months minimum before i decide a dose has stopped doing anything, your mileage will differ 18:29
- two_lifts_a_week — whats a sensible maintenance dose after a year at treatment dose 20:48
- two_lifts_a_week — if i took it 9 days late do i shift the schedule or go back to the old day if you are asking whether to go up, the fact you are asking usually means not yet 21:16
held for months
the ladder in the trials is a starting point, not a schedule you owe anyone
🤝7
steady state is 5 weeks
[edited]unrelated but my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i hold for two months minimum before i decide a dose has stopped doing anything, your mileage will differ
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)✅17🔥4
hold
do you escalate on the calendar or on how you feel
not advice
i went up too fast and im paying for it, do i drop back or ride it out
how long did you hold at 5 before you moved up
end of week thing
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
follow up i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
sorry to jump in how much does the last dose still matter 9 days later
coming back to this with a roughly seven day half-life you are near steady state after about five weeks at a dose
the trials escalated on a fixed schedule because a trial has to. you are not a trial
coming down from 0.5 to 0.25, how bad is the appetite rebound
for the archive the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
💀1
quick one the honest answer is that most of us are running protocols nobody has ever studied
for the archive update question: did anyone who held for 1 months regret it
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlif i hold at 2.5 indefinitely am i losing anything
no trial for that
while im here if it "stopped working after four days" that is almost never pharmacokinetics
✅9
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
pick a day and stick to it
📉15
what does the room think about jumping a rung to catch up
slightly off topic but i drifted from sunday to wednesday over a year and only noticed when i checked the log
thats anecdote
anyone here split their weekly into two and would they do it again
split dosing has no trial behind it. people here do it and report on it, thats all
peptidemeter-summary-sg-1177.pdf
2 pages · 468 KB · not retained in the public archive
update from 11 months ago: held at the same dose the whole time and still losing slowly
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
is week 8 too early to be thinking about the next step
📈3
thats noise
whats a sensible maintenance dose after a year at treatment dose
📉8📈6🤝11
ok so is there a trial anywhere that studied twice weekly, or is it all anecdote
i have been at 1.7 for 25 months and honestly i have stopped wanting to move
go slower
holding is not failing. most people here who lasted two years held at least one dose for months
if i took it 9 days late do i shift the schedule or go back to the old day
if you are asking whether to go up, the fact you are asking usually means not yet
📈1✅9👍5
nobody here can tell you what dose to be on and the ones who try get corrected
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
is there a point where going up stops buying you anything
i drifted from sunday to wednesday over a year and only noticed when i checked the log
😂2
do you count from injection day or from when you actually felt it
the ladder in the trials is a starting point, not a schedule you owe anyone
two weeks is nothing
fridge-thermometer.png
800 × 800 · 425 KB · not retained in the public archive
appetite returning at the end of the week is extremely common and is not the dose failing
the people who do best here are almost always the ones going slowest
my titration ladder took 2 months to climb and i would do it slower again
i would hold
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
the trials escalated on a fixed schedule because a trial has to. you are not a trial