no trial for that
#dosing-titration 2026-05-30
Saturday54 messages11 participantstimes are UTC
Highlights from this day
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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holding is not failing. most people here who lasted two years held at least one dose for months
hold
two weeks is nothing
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whats the smallest step anyone has managed between doses
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the honest answer is that most of us are running protocols nobody has ever studied
if the current dose is still working, going up is spending headroom you might want later
how long did you hold at 2.4 before you moved up
is there a trial anywhere that studied twice weekly, or is it all anecdote
anyone tracked whether a smaller more frequent dose changed their side effects
whats the longest anyone has stayed on one dose
held for months
nobody here can tell you what dose to be on and the ones who try get corrected
the trials escalated on a fixed schedule because a trial has to. you are not a trial
coa-c-4402.pdf
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, i have it written down somewhere
whats a sensible maintenance dose after a year at treatment dose
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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update on the earlier thing is there a point where going up stops buying you anything
update from 23 months ago: held at the same dose the whole time and still losing slowly
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coming back to this with a roughly seven day half-life you are near steady state after about five weeks at a dose
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how do you decide between holding and stepping when both feel wrong
i have been at 1 for 17 months and honestly i have stopped wanting to move
if it "stopped working after four days" that is almost never pharmacokinetics
my titration ladder took 26 months to climb and i would do it slower again
appetite returning at the end of the week is extremely common and is not the dose failing
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
end of week thing
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the ladder in the trials is a starting point, not a schedule you owe anyone
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too early imo
go slower
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgis there any actual reason to escalate every 4 weeks other than the trial did it
not advice
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
coming down from 2.4 to 10, how bad is the appetite rebound
[edited]i hold for two months minimum before i decide a dose has stopped doing anything
do you count from injection day or from when you actually felt it
if you are asking whether to go up, the fact you are asking usually means not yet
small steps are better than big ones and the only reason people take big ones is impatience
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
is week 17 too early to be thinking about the next step
thats noise
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is it normal for appetite to come back at the end of the week
plateau versus set point is not answerable in under six months of data
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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unrelated but what does the room think about jumping a rung to catch up
stepping back down on purpose is a completely reasonable move and this channel should say so more often
i went up too fast and im paying for it, do i drop back or ride it out
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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i escalate on symptoms. if the current dose is still doing something i stay on it
pick a day and stick to it
coming back to this update question: did anyone who held for 18 months regret it