held for months
🔥1📉16
#dosing-titration 2026-05-28
Thursday50 messages8 participantstimes are UTC
Highlights from this day
- noct.titrate — appetite returning at the end of the week is extremely common and is not the dose failing stepping back down on purpose is a completely reasonable move and this… 21:40
- tess_tirz — the trials escalated on a fixed schedule because a trial has to. you are not a trial, i think 21:51
- provincial_pat — holding is not failing. most people here who lasted two years held at least one dose for months 23:00
- provincial_pat — what does the room think about jumping a rung to catch up 23:04
you do not have to escalate at all. that is a real option that gets forgotten
genuine question i went up too fast and im paying for it, do i drop back or ride it out
appetite returning at the end of the week is extremely common and is not the dose failing
stepping back down on purpose is a completely reasonable move and this channel should say so more often
🙏2🧪3
i went from 0.25 to 15 and honestly could not tell the difference in appetite
with a roughly seven day half-life you are near steady state after about five weeks at a dose
my titration ladder took 4 months to climb and i would do it slower again
whats the longest anyone has stayed on one dose
the trials escalated on a fixed schedule because a trial has to. you are not a trial, i think
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg⚠️1🔥3👍15
came down from a treatment dose to maintenance over about three months and it was uneventful
sorry to jump in is there any actual reason to escalate every 4 weeks other than the trial did it
follow up small steps are better than big ones and the only reason people take big ones is impatience, still working it out
the ladder in the trials is a starting point, not a schedule you owe anyone
anyone here split their weekly into two and would they do it again
quick one i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
n of 1
for the archive the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
how do you decide between holding and stepping when both feel wrong
do you count from injection day or from when you actually felt it
follow up a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
*week 22 not week 5
plateau versus set point is not answerable in under six months of data
the honest answer is that most of us are running protocols nobody has ever studied
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
stepping back down on purpose is a completely reasonable move and this channel should say so more often
no trial for that
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
too early imo
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
📈1
two weeks is nothing
half life is a week
my dose day has drifted 4 days later over 17 months, does it matter
is it normal for appetite to come back at the end of the week
the people who do best here are almost always the ones going slowest, ymmv
ok so i escalate on symptoms. if the current dose is still doing something i stay on it
if it "stopped working after four days" that is almost never pharmacokinetics
if the current dose is still working, going up is spending headroom you might want later
not advice
how do you tell a plateau from just being at your set point
hold
is week 16 too early to be thinking about the next step
holding is not failing. most people here who lasted two years held at least one dose for months
🙏4💀2❤️14
end of week thing
what does the room think about jumping a rung to catch up
❤️4💀6
if i took it 9 days late do i shift the schedule or go back to the old day
nobody here can tell you what dose to be on and the ones who try get corrected, ill dig out the number
do you escalate on the calendar or on how you feel
whats your rule for when a side effect means hold rather than push
coa-b-0114.pdf
1 page · 204 KB · not retained in the public archive
23:30ferrous_ash pinned a message to this channel
i hold for two months minimum before i decide a dose has stopped doing anything
i drifted from sunday to wednesday over a year and only noticed when i checked the log