too early imo
#dosing-titration 2026-05-26
Tuesday66 messages12 participantstimes are UTC
Highlights from this day
the honest answer is that most of us are running protocols nobody has ever studied
do you count from injection day or from when you actually felt it
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i went from 2 to 15 and honestly could not tell the difference in appetite, not advice obviously
go slower
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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i went up too fast and im paying for it, do i drop back or ride it out
with a roughly seven day half-life you are near steady state after about five weeks at a dose, we shall see
if i took it 3 days late do i shift the schedule or go back to the old day
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlhow long did you hold at 2.4 before you moved up
[edited]update from 25 months ago: held at the same dose the whole time and still losing slowly
is there any actual reason to escalate every 4 weeks other than the trial did it
pick a day and stick to it
hold
anyone here split their weekly into two and would they do it again
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ok so i escalate on symptoms. if the current dose is still doing something i stay on it
if you are asking whether to go up, the fact you are asking usually means not yet, take that with a pinch of salt
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
no trial for that
has anyone gone up and then straight back down and been glad they tried
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is there a trial anywhere that studied twice weekly, or is it all anecdote
half life is a week
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split dosing has no trial behind it. people here do it and report on it, thats all
for the archive is it normal for appetite to come back at the end of the week
[edited]came down from a treatment dose to maintenance over about three months and it was uneventful
ok so whats a sensible maintenance dose after a year at treatment dose
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
came down, no regrets
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two weeks is nothing
Recon calculator: 40mg in 3ml = 2mg/ml.
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i would hold
whats your rule for when a side effect means hold rather than push
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is there a point where going up stops buying you anything
if the current dose is still working, going up is spending headroom you might want later, someone check my working
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thats noise
right so does a missed week reset anything or do you just carry on
right so if you are going up because the scale stalled for two weeks, wait. two weeks is noise
thats normal
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whats the longest anyone has stayed on one dose
*VendorInvestigate not the other one
the trials escalated on a fixed schedule because a trial has to. you are not a trial
you do not have to escalate at all. that is a real option that gets forgotten
update question: did anyone who held for 14 months regret it
the people who do best here are almost always the ones going slowest
end of week thing
my titration ladder took 3 months to climb and i would do it slower again
[edited]not advice
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
while im here if i hold at 1 indefinitely am i losing anything
what does the room think about jumping a rung to catch up
holding is not failing. most people here who lasted two years held at least one dose for months
held for months
anyone tracked whether a smaller more frequent dose changed their side effects
appetite returning at the end of the week is extremely common and is not the dose failing
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg*PeptideMeter not the other one
how do you tell a plateau from just being at your set point
my dose day has drifted 9 days later over 8 months, does it matter
is week 25 too early to be thinking about the next step
coming down from 7.5 to 0.25, how bad is the appetite rebound
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do you escalate on the calendar or on how you feel
small steps are better than big ones and the only reason people take big ones is impatience
no trial for that
while im here the ladder in the trials is a starting point, not a schedule you owe anyone
whats the smallest step anyone has managed between doses
nobody here can tell you what dose to be on and the ones who try get corrected
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