#dosing-titration 2026-05-20

if you are going up because the scale stalled for two weeks, wait. two weeks is noise, take that with a pinch of salt

hold

how do you tell a plateau from just being at your set point

the ladder in the trials is a starting point, not a schedule you owe anyone

how long did you hold at 1.7 before you moved up

small steps are better than big ones and the only reason people take big ones is impatience

slightly off topic but anyone here split their weekly into two and would they do it again

whats the longest anyone has stayed on one dose

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess

sorry to jump in is week 33 too early to be thinking about the next step

the trials escalated on a fixed schedule because a trial has to. you are not a trial

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, from memory

has anyone gone up and then straight back down and been glad they tried

held for months

my titration ladder took 22 months to climb and i would do it slower again

whats your rule for when a side effect means hold rather than push

holding is not failing. most people here who lasted two years held at least one dose for months

Purity check: no report on file for lot SG-1177. Nothing logged either way.

my dose day has drifted 9 days later over 7 months, does it matter

i would hold

came down from a treatment dose to maintenance over about three months and it was uneventful

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

do you count from injection day or from when you actually felt it

stepping back down on purpose is a completely reasonable move and this channel should say so more often

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

thats noise

not advice

whats a sensible maintenance dose after a year at treatment dose

is there any actual reason to escalate every 4 weeks other than the trial did it

too early imo

is there a trial anywhere that studied twice weekly, or is it all anecdote

plateau versus set point is not answerable in under six months of data, still working it out

you do not have to escalate at all. that is a real option that gets forgotten, take that with a pinch of salt

thats anecdote

*that should say weekly

i escalate on symptoms. if the current dose is still doing something i stay on it

two weeks is nothing

i went up too fast and im paying for it, do i drop back or ride it out

if the current dose is still working, going up is spending headroom you might want later, anyway

what does the room think about jumping a rung to catch up

if it "stopped working after four days" that is almost never pharmacokinetics

thats normal

right so update from 25 months ago: held at the same dose the whole time and still losing slowly, your mileage will differ

appetite returning at the end of the week is extremely common and is not the dose failing

if i took it 3 days late do i shift the schedule or go back to the old day

n of 1

pick a day and stick to it

Reminder for triple_ag_tom: dose day is today. Set 8 days ago.