vialroom

#dosing-titration 2026-02-11

Wednesday14 messages5 participantstimes are UTC
Highlights from this day
  • vat_on_import — has anyone gone up and then straight back down and been glad they tried 22:50
  • surpass_two — whats your rule for when a side effect means hold rather than push if the current dose is still working, going up is spending headroom you might want later 23:01
  • meniscus_mel — how do you tell a plateau from just being at your set point 23:09
  • elm_escalates — if you are asking whether to go up, the fact you are asking usually means not yet my titration ladder took 1 months to climb and i would do it slower again 23:27
  • elm_escalates — i escalate on symptoms. if the current dose is still doing something i stay on it 23:37
VO

if i took it 9 days late do i shift the schedule or go back to the old day

has anyone gone up and then straight back down and been glad they tried

🤝14

you do not have to escalate at all. that is a real option that gets forgotten, we shall see

ST

i have been at 7.5 for 16 months and honestly i have stopped wanting to move

whats your rule for when a side effect means hold rather than push
if the current dose is still working, going up is spending headroom you might want later

MM

how do you tell a plateau from just being at your set point

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
GG

small steps are better than big ones and the only reason people take big ones is impatience

MM

if the current dose is still working, going up is spending headroom you might want later

[edited]

if you are asking whether to go up, the fact you are asking usually means not yet
my titration ladder took 1 months to climb and i would do it slower again

EE

i escalate on symptoms. if the current dose is still doing something i stay on it

⚠️14

does a missed week reset anything or do you just carry on
plateau versus set point is not answerable in under six months of data