while im here my dose day has drifted 3 days later over 2 months, does it matter
#dosing-titration 2026-02-10
Tuesday27 messages5 participantstimes are UTC
Highlights from this day
- lisbon_lot — i hold for two months minimum before i decide a dose has stopped doing anything 21:47
- VialBot — Purity check: no report on file for lot B-0114. Nothing logged either way. 21:50
- lisbon_lot — i went up too fast and im paying for it, do i drop back or ride it out 22:16
- lisbon_lot — you do not have to escalate at all. that is a real option that gets forgotten the trials escalated on a fixed schedule because a trial has to. you are not a trial 23:08
i hold for two months minimum before i decide a dose has stopped doing anything
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Purity check: no report on file for lot B-0114. Nothing logged either way.
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the honest answer is that most of us are running protocols nobody has ever studied, not advice obviously
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, anyway
i went from 10 to 2 and honestly could not tell the difference in appetite
held for months
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is there a point where going up stops buying you anything
sorry to jump in with a roughly seven day half-life you are near steady state after about five weeks at a dose
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plateau versus set point is not answerable in under six months of data
go slower
i went up too fast and im paying for it, do i drop back or ride it out
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two weeks is nothing
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
whats your rule for when a side effect means hold rather than push
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slightly off topic but i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
sorry to jump in whats the smallest step anyone has managed between doses
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
is it normal for appetite to come back at the end of the week
if it "stopped working after four days" that is almost never pharmacokinetics
pick a day and stick to it
you do not have to escalate at all. that is a real option that gets forgotten
the trials escalated on a fixed schedule because a trial has to. you are not a trial
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, i could be wrong
steady state is 5 weeks
coming back to this whats a sensible maintenance dose after a year at treatment dose
anyone here split their weekly into two and would they do it again