held for months
#dosing-titration 2026-01-17
Saturday37 messages8 participantstimes are UTC
Highlights from this day
- lot_number_lou — quick one my titration ladder took 4 months to climb and i would do it slower again, from memory 08:15
- VialBot — Reminder for tb500_tobias: dose day is today. Set 2 days ago. 08:42
- deamidation — i escalate on symptoms. if the current dose is still doing something i stay on it, i think appetite returning at the end of the week is extremely common and is not… 13:38
- VialBot — Purity check: no report on file for lot C-4402. Nothing logged either way. 14:03
i would hold
quick one my titration ladder took 4 months to climb and i would do it slower again, from memory
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the ladder in the trials is a starting point, not a schedule you owe anyone, i think
Reminder for tb500_tobias: dose day is today. Set 2 days ago.
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whats the longest anyone has stayed on one dose
does a missed week reset anything or do you just carry on
do you tell your prescriber you held or do you just hold
how much does the last dose still matter 3 days later
holding is not failing. most people here who lasted two years held at least one dose for months
i went up too fast and im paying for it, do i drop back or ride it out
whats your rule for when a side effect means hold rather than push
coming down from 2.5 to 7.5, how bad is the appetite rebound
too early imo
plateau versus set point is not answerable in under six months of data
if i hold at 0.5 indefinitely am i losing anything
stepping back down on purpose is a completely reasonable move and this channel should say so more often
the people who do best here are almost always the ones going slowest
follow up if it "stopped working after four days" that is almost never pharmacokinetics, i think
no trial for that
is it normal for appetite to come back at the end of the week
while im here the honest answer is that most of us are running protocols nobody has ever studied, ask me again in a month
is there any actual reason to escalate every 4 weeks other than the trial did it
split dosing has no trial behind it. people here do it and report on it, thats all
i have been at 2 for 14 months and honestly i have stopped wanting to move
quick one the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, we shall see
whats the smallest step anyone has managed between doses
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
i escalate on symptoms. if the current dose is still doing something i stay on it, i think
appetite returning at the end of the week is extremely common and is not the dose failing
came down, no regrets
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Purity check: no report on file for lot C-4402. Nothing logged either way.
came down from a treatment dose to maintenance over about three months and it was uneventful
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
do you escalate on the calendar or on how you feel
is there a trial anywhere that studied twice weekly, or is it all anecdote
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, for what its worth