with a roughly seven day half-life you are near steady state after about five weeks at a dose
#dosing-titration 2026-01-16
Friday47 messages11 participantstimes are UTC
Highlights from this day
- taper_tess — anyone tracked whether a smaller more frequent dose changed their side effects 20:38
- taper_or_not — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month the people who do best… 21:34
- taper_or_not — the people who do best here are almost always the ones going slowest, ask me again in a month 21:35
what does the room think about jumping a rung to catch up
how much does the last dose still matter 8 days later
i escalate on symptoms. if the current dose is still doing something i stay on it
if i hold at 0.25 indefinitely am i losing anything
i drifted from sunday to wednesday over a year and only noticed when i checked the log
unrelated but stepping back down on purpose is a completely reasonable move and this channel should say so more often
is week 13 too early to be thinking about the next step
my dose day has drifted 5 days later over 17 months, does it matter
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anyone tracked whether a smaller more frequent dose changed their side effects
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)whats a sensible maintenance dose after a year at treatment dose
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
not advice
how do you tell a plateau from just being at your set point
i went from 15 to 1 and honestly could not tell the difference in appetite
thats anecdote
the honest answer is that most of us are running protocols nobody has ever studied
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is there a point where going up stops buying you anything
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plateau versus set point is not answerable in under six months of data
hold
held for months
i have been at 1 for 9 months and honestly i have stopped wanting to move
quick one you do not have to escalate at all. that is a real option that gets forgotten
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month
the people who do best here are almost always the ones going slowest
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the people who do best here are almost always the ones going slowest, ask me again in a month
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end of week thing
On this day 9 years ago this channel logged 92 messages.
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
no trial for that
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
sorry to jump in update question: did anyone who held for 26 months regret it
*sorry, WWB
steady state is 5 weeks
ok so whats the longest anyone has stayed on one dose
if you are asking whether to go up, the fact you are asking usually means not yet
the trials escalated on a fixed schedule because a trial has to. you are not a trial
my titration ladder took 25 months to climb and i would do it slower again
update on the earlier thing if the current dose is still working, going up is spending headroom you might want later
holding is not failing. most people here who lasted two years held at least one dose for months
i hold for two months minimum before i decide a dose has stopped doing anything, someone check my working
do you tell your prescriber you held or do you just hold
whats your rule for when a side effect means hold rather than push