if the current dose is still working, going up is spending headroom you might want later
#dosing-titration 2025-12-05
Friday54 messages12 participantstimes are UTC
Highlights from this day
if i took it 5 days late do i shift the schedule or go back to the old day
held for months
came down, no regrets
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no trial for that
split dosing has no trial behind it. people here do it and report on it, thats all
is there any actual reason to escalate every 4 weeks other than the trial did it
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half life is a week
what does the room think about jumping a rung to catch up
*VendorInvestigate not the other one
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, ymmv
holding is not failing. most people here who lasted two years held at least one dose for months
anyone tracked whether a smaller more frequent dose changed their side effects
slightly off topic but is it normal for appetite to come back at the end of the week
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, take that with a pinch of salt
while im here how do you decide between holding and stepping when both feel wrong
thats noise
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genuine question i drifted from sunday to wednesday over a year and only noticed when i checked the log
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
the ladder in the trials is a starting point, not a schedule you owe anyone
coming down from 2.4 to 10, how bad is the appetite rebound
coming back to this how long did you hold at 2.5 before you moved up
anyone here split their weekly into two and would they do it again
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
go slower
if you are asking whether to go up, the fact you are asking usually means not yet
genuine question whats the longest anyone has stayed on one dose
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two weeks is nothing
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the honest answer is that most of us are running protocols nobody has ever studied
update on the earlier thing after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
with a roughly seven day half-life you are near steady state after about five weeks at a dose
follow up the trials escalated on a fixed schedule because a trial has to. you are not a trial, someone check my working
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, ymmv
my dose day has drifted 7 days later over 9 months, does it matter
plateau versus set point is not answerable in under six months of data
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i went from 12 to 1 and honestly could not tell the difference in appetite
i escalate on symptoms. if the current dose is still doing something i stay on it, we shall see
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
you do not have to escalate at all. that is a real option that gets forgotten
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
whats your rule for when a side effect means hold rather than push
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
came down from a treatment dose to maintenance over about three months and it was uneventful
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too early imo
do you escalate on the calendar or on how you feel
steady state is 5 weeks
[edited]the people who do best here are almost always the ones going slowest
end of week thing
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do you tell your prescriber you held or do you just hold
how much does the last dose still matter 2 days later
thats anecdote
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
do you count from injection day or from when you actually felt it
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if i hold at 12 indefinitely am i losing anything