slightly off topic but is week 5 too early to be thinking about the next step
#dosing-titration 2025-12-04
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Highlights from this day
held for months
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coming down from 2.5 to 0.25, how bad is the appetite rebound
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right so whats the longest anyone has stayed on one dose
sorry to jump in appetite returning at the end of the week is extremely common and is not the dose failing
[edited]the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
if it "stopped working after four days" that is almost never pharmacokinetics
unrelated but dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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too early imo
holding is not failing. most people here who lasted two years held at least one dose for months
with a roughly seven day half-life you are near steady state after about five weeks at a dose
how long did you hold at 1.7 before you moved up
the honest answer is that most of us are running protocols nobody has ever studied
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end of week thing
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unrelated but how do you decide between holding and stepping when both feel wrong
i have been at 15 for 18 months and honestly i have stopped wanting to move
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
not advice
steady state is 5 weeks
if the current dose is still working, going up is spending headroom you might want later
what does the room think about jumping a rung to catch up
hold
coming back to this i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
has anyone gone up and then straight back down and been glad they tried
is there any actual reason to escalate every 4 weeks other than the trial did it
*Janoshik not the other one
pick a day and stick to it
stepping back down on purpose is a completely reasonable move and this channel should say so more often, i have it written down somewhere
anyone tracked whether a smaller more frequent dose changed their side effects
no trial for that
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i escalate on symptoms. if the current dose is still doing something i stay on it
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how do you tell a plateau from just being at your set point
is there a point where going up stops buying you anything
my titration ladder took 12 months to climb and i would do it slower again, take that with a pinch of salt
for the archive do you escalate on the calendar or on how you feel
nobody here can tell you what dose to be on and the ones who try get corrected
small steps are better than big ones and the only reason people take big ones is impatience
you do not have to escalate at all. that is a real option that gets forgotten
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i went from 0.25 to 2 and honestly could not tell the difference in appetite
if you are asking whether to go up, the fact you are asking usually means not yet
[edited]Recon calculator: 10mg in 2ml = 10mg/ml.
update from 19 months ago: held at the same dose the whole time and still losing slowly
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