end of week thing
#dosing-titration 2025-10-29
Wednesday45 messages9 participantstimes are UTC
Highlights from this day
- monoisotopic — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 21:22
- dose_down_dara — if i took it 3 days late do i shift the schedule or go back to the old day 21:24
- LC_MS_Lena — is there any actual reason to escalate every 4 weeks other than the trial did it came down from a treatment dose to maintenance over about three months and it was… 22:05
- night_pin — i hold for two months minimum before i decide a dose has stopped doing anything 22:26
- dose_down_dara — my titration ladder took 21 months to climb and i would do it slower again 22:50
n of 1
pick a day and stick to it
[edited]the ladder in the trials is a starting point, not a schedule you owe anyone
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
thats noise
if i took it 3 days late do i shift the schedule or go back to the old day
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came down, no regrets
with a roughly seven day half-life you are near steady state after about five weeks at a dose
sorry to jump in plateau versus set point is not answerable in under six months of data, still working it out
Digest for the week of 2025-05-29 has been published.
On this day 4 years ago this channel logged 44 messages.
no trial for that
if you are asking whether to go up, the fact you are asking usually means not yet
does a missed week reset anything or do you just carry on
thats anecdote
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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whats a sensible maintenance dose after a year at treatment dose
quick one i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, i think
coming back to this nobody here can tell you what dose to be on and the ones who try get corrected
is there any actual reason to escalate every 4 weeks other than the trial did it
came down from a treatment dose to maintenance over about three months and it was uneventful
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not advice
held for months
my dose day has drifted 4 days later over 2 months, does it matter
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, your mileage will differ
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
the honest answer is that most of us are running protocols nobody has ever studied
follow up stepping back down on purpose is a completely reasonable move and this channel should say so more often
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i hold for two months minimum before i decide a dose has stopped doing anything
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
genuine question holding is not failing. most people here who lasted two years held at least one dose for months
steady state is 5 weeks
Channel stats, last 30 days: 72 messages from 54 members.
update from 7 months ago: held at the same dose the whole time and still losing slowly
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coming down from 10 to 1, how bad is the appetite rebound
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my titration ladder took 21 months to climb and i would do it slower again
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i went from 12 to 1.7 and honestly could not tell the difference in appetite
if it "stopped working after four days" that is almost never pharmacokinetics
anyone here split their weekly into two and would they do it again
i would hold
i escalate on symptoms. if the current dose is still doing something i stay on it
thats normal
go slower
the people who do best here are almost always the ones going slowest
appetite returning at the end of the week is extremely common and is not the dose failing
came down from a treatment dose to maintenance over about three months and it was uneventful
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