follow up i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
#dosing-titration 2025-10-06
Monday28 messages6 participantstimes are UTC
Highlights from this day
- tokyo_taper — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 14:15
- two_eight_c — coming back to this what does the room think about jumping a rung to catch up 14:27
- thursday_thea — if it "stopped working after four days" that is almost never pharmacokinetics 14:39
- stopped_and_regained — my titration ladder took 18 months to climb and i would do it slower again 16:52
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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plateau versus set point is not answerable in under six months of data, thats just me
the people who do best here are almost always the ones going slowest
the ladder in the trials is a starting point, not a schedule you owe anyone
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
coming back to this what does the room think about jumping a rung to catch up
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if it "stopped working after four days" that is almost never pharmacokinetics
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you do not have to escalate at all. that is a real option that gets forgotten, n of 1 obviously
anyone tracked whether a smaller more frequent dose changed their side effects
if you are asking whether to go up, the fact you are asking usually means not yet
the honest answer is that most of us are running protocols nobody has ever studied
how long did you hold at 5 before you moved up
how do you tell a plateau from just being at your set point
holding is not failing. most people here who lasted two years held at least one dose for months
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came down from a treatment dose to maintenance over about three months and it was uneventful, take that with a pinch of salt
i hold for two months minimum before i decide a dose has stopped doing anything, ymmv
sorry to jump in i escalate on symptoms. if the current dose is still doing something i stay on it
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coming down from 2 to 2.4, how bad is the appetite rebound
two weeks is nothing
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
n of 1
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i would hold
my titration ladder took 18 months to climb and i would do it slower again
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whats the longest anyone has stayed on one dose
[edited]if i hold at 12 indefinitely am i losing anything
not advice
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)update from 10 months ago: held at the same dose the whole time and still losing slowly, ill dig out the number
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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