do you count from injection day or from when you actually felt it
#dosing-titration 2025-06-20
Friday41 messages10 participantstimes are UTC
Highlights from this day
- night_pin — i went from 15 to 10 and honestly could not tell the difference in appetite 16:42
- turnaround_tam — whats the longest anyone has stayed on one dose 19:39
- cold_chain_cmdr — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, ill dig out the number 20:58
right so if the current dose is still working, going up is spending headroom you might want later
two weeks is nothing
i went from 15 to 10 and honestly could not tell the difference in appetite
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end of week thing
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held for months
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is there any actual reason to escalate every 4 weeks other than the trial did it
i went up too fast and im paying for it, do i drop back or ride it out
you do not have to escalate at all. that is a real option that gets forgotten
is there a point where going up stops buying you anything
if it "stopped working after four days" that is almost never pharmacokinetics
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
coming down from 0.25 to 15, how bad is the appetite rebound
hold
stepping back down on purpose is a completely reasonable move and this channel should say so more often
do you tell your prescriber you held or do you just hold
pinch_not_stretchif you are going up because the scale stalled for two weeks, wait. two weeks is noise
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
follow up split dosing has no trial behind it. people here do it and report on it, thats all, n of 1 obviously
go slower
appetite returning at the end of the week is extremely common and is not the dose failing
plateau versus set point is not answerable in under six months of data
i have been at 5 for 4 months and honestly i have stopped wanting to move
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
anyone tracked whether a smaller more frequent dose changed their side effects
the people who do best here are almost always the ones going slowest
update from 4 months ago: held at the same dose the whole time and still losing slowly
thats anecdote
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thats normal
genuine question i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i escalate on symptoms. if the current dose is still doing something i stay on it
the people who do best here are almost always the ones going slowest
whats the longest anyone has stayed on one dose
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holding is not failing. most people here who lasted two years held at least one dose for months
i would hold
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the honest answer is that most of us are running protocols nobody has ever studied
Digest for the week of 2024-09-27 has been published.
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, ill dig out the number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if you are asking whether to go up, the fact you are asking usually means not yet
pick a day and stick to it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
half life is a week
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n of 1