i drifted from sunday to wednesday over a year and only noticed when i checked the log
#dosing-titration 2025-06-18
Wednesday41 messages10 participantstimes are UTC
Highlights from this day
- panel_before_after — anyone here split their weekly into two and would they do it again 19:11
- VialBot — Digest for the week of 2024-08-01 has been published. 19:36
- chain_of_custody — whats the longest anyone has stayed on one dose 20:16
- chain_of_custody — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 20:26
anyone here split their weekly into two and would they do it again
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*week 30 not week 4
how much does the last dose still matter 5 days later
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
is there a trial anywhere that studied twice weekly, or is it all anecdote
with a roughly seven day half-life you are near steady state after about five weeks at a dose
my titration ladder took 1 months to climb and i would do it slower again
end of week thing
Digest for the week of 2024-08-01 has been published.
has anyone gone up and then straight back down and been glad they tried
quick one do you tell your prescriber you held or do you just hold
half life is a week
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[edited]update question: did anyone who held for 13 months regret it
how long did you hold at 0.25 before you moved up
how do you tell a plateau from just being at your set point
appetite returning at the end of the week is extremely common and is not the dose failing
hold
whats the longest anyone has stayed on one dose
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlthats anecdote
whats your rule for when a side effect means hold rather than push
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
coming down from 2.4 to 7.5, how bad is the appetite rebound
update on the earlier thing if you are going up because the scale stalled for two weeks, wait. two weeks is noise
stepping back down on purpose is a completely reasonable move and this channel should say so more often
if the current dose is still working, going up is spending headroom you might want later
i went from 0.25 to 5 and honestly could not tell the difference in appetite
[edited]holding is not failing. most people here who lasted two years held at least one dose for months
came down from a treatment dose to maintenance over about three months and it was uneventful
if it "stopped working after four days" that is almost never pharmacokinetics
pick a day and stick to it
go slower
coming back to this the people who do best here are almost always the ones going slowest
for the archive the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i would hold
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held for months
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plateau versus set point is not answerable in under six months of data