n of 1
#dosing-titration 2025-06-02
Monday39 messages10 participantstimes are UTC
Highlights from this day
- lyophile_liv — update question: did anyone who held for 12 months regret it 14:08
- lyophile_liv — i escalate on symptoms. if the current dose is still doing something i stay on it 15:21
- private_script_pri — right so you do not have to escalate at all. that is a real option that gets forgotten the honest answer is that most of us are running protocols nobody has ever… 16:09
- amsterdam_aliquot — do you escalate on the calendar or on how you feel 16:32
- VialBot — Reminder set. I will post here in 7 days. 18:32
is there a point where going up stops buying you anything
the honest answer is that most of us are running protocols nobody has ever studied, your mileage will differ
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
two weeks is nothing
for the archive nobody here can tell you what dose to be on and the ones who try get corrected
half life is a week
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
update question: did anyone who held for 12 months regret it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgif you are asking whether to go up, the fact you are asking usually means not yet, thats just me
ok so the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
[edited]how do you decide between holding and stepping when both feel wrong
no trial for that
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i escalate on symptoms. if the current dose is still doing something i stay on it
thats anecdote
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
plateau versus set point is not answerable in under six months of data
holding is not failing. most people here who lasted two years held at least one dose for months
genuine question i went from 0.5 to 12 and honestly could not tell the difference in appetite
the trials escalated on a fixed schedule because a trial has to. you are not a trial
sorry to jump in update from 10 months ago: held at the same dose the whole time and still losing slowly
right so you do not have to escalate at all. that is a real option that gets forgotten
the honest answer is that most of us are running protocols nobody has ever studied
🎉17⚠️7❤️9
if i took it 8 days late do i shift the schedule or go back to the old day
appetite returning at the end of the week is extremely common and is not the dose failing
thats noise
not advice
end of week thing
i went up too fast and im paying for it, do i drop back or ride it out
do you escalate on the calendar or on how you feel
📈8
came down, no regrets
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgis there a trial anywhere that studied twice weekly, or is it all anecdote
thats normal
how long did you hold at 12 before you moved up
pick a day and stick to it
held for months
anyone here split their weekly into two and would they do it again
my titration ladder took 23 months to climb and i would do it slower again
if it "stopped working after four days" that is almost never pharmacokinetics
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, we shall see
Reminder set. I will post here in 7 days.
🙏13👀3