hold
#dosing-titration 2025-05-29
Thursday16 messages3 participantstimes are UTC
Highlights from this day
- seoul_swirl — quick one a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 20:11
- area_percent — is it normal for appetite to come back at the end of the week 21:41
- area_percent — how do you tell a plateau from just being at your set point 21:46
whats the smallest step anyone has managed between doses
thats normal
quick one a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if you are asking whether to go up, the fact you are asking usually means not yet
stepping back down on purpose is a completely reasonable move and this channel should say so more often
appetite returning at the end of the week is extremely common and is not the dose failing
with a roughly seven day half-life you are near steady state after about five weeks at a dose
end of week thing
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too early imo
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follow up does a missed week reset anything or do you just carry on
not advice
no trial for that
is it normal for appetite to come back at the end of the week
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how do you tell a plateau from just being at your set point
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
small steps are better than big ones and the only reason people take big ones is impatience