vialroom

#dosing-titration 2025-03-27

Thursday20 messages5 participantstimes are UTC
Highlights from this day
  • never_for_sale — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 13:06
  • never_for_sale — stepping back down on purpose is a completely reasonable move and this channel should say so more often, anyway 13:13
  • never_for_sale — is there any actual reason to escalate every 4 weeks other than the trial did it the ladder in the trials is a starting point, not a schedule you owe anyone 14:31
  • split_dose_sam — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month 16:24

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

NF

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

PP

i went from 2.4 to 10 and honestly could not tell the difference in appetite

NF

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

appetite returning at the end of the week is extremely common and is not the dose failing

NF

stepping back down on purpose is a completely reasonable move and this channel should say so more often, anyway

⚠️1
NF

i drifted from sunday to wednesday over a year and only noticed when i checked the log

MP

if you are asking whether to go up, the fact you are asking usually means not yet

MP

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step

NF

is there any actual reason to escalate every 4 weeks other than the trial did it
the ladder in the trials is a starting point, not a schedule you owe anyone

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MP

whats the smallest step anyone has managed between doses

SD

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month

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SD

small steps are better than big ones and the only reason people take big ones is impatience