for the archive if i hold at 5 indefinitely am i losing anything
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#dosing-titration 2025-03-22
Saturday40 messages6 participantstimes are UTC
Highlights from this day
- apob_over_ldl — for the archive if i hold at 5 indefinitely am i losing anything 17:15
- apob_over_ldl — stepping back down on purpose is a completely reasonable move and this channel should say so more often 17:29
- stack_sceptic — i hold for two months minimum before i decide a dose has stopped doing anything 18:09
- courier_vs_post — does a missed week reset anything or do you just carry on 18:42
- courier_vs_post — genuine question holding is not failing. most people here who lasted two years held at least one dose for months 20:15
my titration ladder took 2 months to climb and i would do it slower again
i escalate on symptoms. if the current dose is still doing something i stay on it
stepping back down on purpose is a completely reasonable move and this channel should say so more often
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
pick a day and stick to it
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
too early imo
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held for months
my dose day has drifted 8 days later over 18 months, does it matter
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
how long did you hold at 7.5 before you moved up
i hold for two months minimum before i decide a dose has stopped doing anything
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update question: did anyone who held for 6 months regret it
came down, no regrets
no trial for that
plateau versus set point is not answerable in under six months of data
with a roughly seven day half-life you are near steady state after about five weeks at a dose, thats one data point
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
does a missed week reset anything or do you just carry on
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*week 14 not week 7
not advice
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
hold
is it normal for appetite to come back at the end of the week
end of week thing
quick one after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
if i took it 6 days late do i shift the schedule or go back to the old day
split dosing has no trial behind it. people here do it and report on it, thats all
do you count from injection day or from when you actually felt it
anyone tracked whether a smaller more frequent dose changed their side effects
anyone here split their weekly into two and would they do it again
if it "stopped working after four days" that is almost never pharmacokinetics
unrelated but the trials escalated on a fixed schedule because a trial has to. you are not a trial
go slower
the people who do best here are almost always the ones going slowest
appetite returning at the end of the week is extremely common and is not the dose failing
for the archive came down from a treatment dose to maintenance over about three months and it was uneventful
i drifted from sunday to wednesday over a year and only noticed when i checked the log
genuine question holding is not failing. most people here who lasted two years held at least one dose for months
whats a sensible maintenance dose after a year at treatment dose