n of 1
Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
n of 1
#dosing-titration 2025-02-09
Sunday35 messages8 participantstimes are UTC
Highlights from this day
- slow.taper — if you are going up because the scale stalled for two weeks, wait. two weeks is noise the ladder in the trials is a starting point, not a schedule you owe anyone 17:03
- quiet_head_qi — has anyone gone up and then straight back down and been glad they tried 20:07
- slow.taper — whats your rule for when a side effect means hold rather than push 22:07
no trial for that
i drifted from sunday to wednesday over a year and only noticed when i checked the log, ymmv
site-rotation-map.png
1000 × 700 · 362 KB · not retained in the public archive
the honest answer is that most of us are running protocols nobody has ever studied
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
Inter-lab diff for lot B-0329: 98.6% vs 97.4%. Within expected range.
is there a trial anywhere that studied twice weekly, or is it all anecdote
if it "stopped working after four days" that is almost never pharmacokinetics
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
the ladder in the trials is a starting point, not a schedule you owe anyone
😂10
appetite returning at the end of the week is extremely common and is not the dose failing, i have it written down somewhere
came down from a treatment dose to maintenance over about three months and it was uneventful
i went from 2 to 7.5 and honestly could not tell the difference in appetite
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
i have been at 2.5 for 17 months and honestly i have stopped wanting to move
👍1
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, from memory
not advice
thats normal
[edited]👍17🎉1🔥2
i went up too fast and im paying for it, do i drop back or ride it out
slightly off topic but the ladder in the trials is a starting point, not a schedule you owe anyone, happy to be corrected
how do you decide between holding and stepping when both feel wrong
end of week thing
i hold for two months minimum before i decide a dose has stopped doing anything
👀1💀1📈2
steady state is 5 weeks
you do not have to escalate at all. that is a real option that gets forgotten
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
anyone tracked whether a smaller more frequent dose changed their side effects
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
has anyone gone up and then straight back down and been glad they tried
🧪9🧊7
for the archive stepping back down on purpose is a completely reasonable move and this channel should say so more often
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
if the current dose is still working, going up is spending headroom you might want later
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
pick a day and stick to it
[edited]held for months
whats your rule for when a side effect means hold rather than push
👀1🧊9
Batch lookup F-1330: 8 independent reports on file, earliest 2024-04-17.