i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
#dosing-titration 2025-02-08
Saturday41 messages10 participantstimes are UTC
Highlights from this day
- mg_per_ml — whats the smallest step anyone has managed between doses 21:09
- slow.taper — the people who do best here are almost always the ones going slowest 21:13
- logrotate — is week 29 too early to be thinking about the next step i drifted from sunday to wednesday over a year and only noticed when i checked the log 21:34
how do you decide between holding and stepping when both feel wrong
i drifted from sunday to wednesday over a year and only noticed when i checked the log
go slower
whats the smallest step anyone has managed between doses
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the people who do best here are almost always the ones going slowest
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i have been at 1.7 for 14 months and honestly i have stopped wanting to move
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came down from a treatment dose to maintenance over about three months and it was uneventful
if the current dose is still working, going up is spending headroom you might want later
[edited]i escalate on symptoms. if the current dose is still doing something i stay on it
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
update on the earlier thing whats a sensible maintenance dose after a year at treatment dose
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ok so if you are going up because the scale stalled for two weeks, wait. two weeks is noise
is week 29 too early to be thinking about the next step
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
if i hold at 1.7 indefinitely am i losing anything
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
holding is not failing. most people here who lasted two years held at least one dose for months
right so is there a point where going up stops buying you anything
[edited]small steps are better than big ones and the only reason people take big ones is impatience, thats one data point
Archive lookup: declared_value first appears in this channel on 2024-11-08.
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half life is a week
is there any actual reason to escalate every 4 weeks other than the trial did it
whats your rule for when a side effect means hold rather than push
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has anyone gone up and then straight back down and been glad they tried
plateau versus set point is not answerable in under six months of data
stepping back down on purpose is a completely reasonable move and this channel should say so more often
[edited]my titration ladder took 6 months to climb and i would do it slower again
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, ask me again in a month
held for months
no trial for that
if it "stopped working after four days" that is almost never pharmacokinetics
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update question: did anyone who held for 16 months regret it
anyone here split their weekly into two and would they do it again
too early imo
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not advice
thats noise
[redacted at member request] · archive policy
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for the archive the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, from memory
with a roughly seven day half-life you are near steady state after about five weeks at a dose
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored