i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
#dosing-titration 2025-01-27
Monday30 messages7 participantstimes are UTC
Highlights from this day
- knees_first — how long did you hold at 2.5 before you moved up 08:39
- secretagogue_sy — if i hold at 10 indefinitely am i losing anything 08:55
- secretagogue_sy — whats your rule for when a side effect means hold rather than push 08:56
- spreadsheet_stu — came down from a treatment dose to maintenance over about three months and it was uneventful, i have it written down somewhere 09:45
- spreadsheet_stu — you do not have to escalate at all. that is a real option that gets forgotten 09:53
how do you tell a plateau from just being at your set point
how long did you hold at 2.5 before you moved up
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
if i hold at 10 indefinitely am i losing anything
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
whats your rule for when a side effect means hold rather than push
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came down, no regrets
nobody here can tell you what dose to be on and the ones who try get corrected
thats normal
go slower
unrelated but is there any actual reason to escalate every 4 weeks other than the trial did it
my titration ladder took 7 months to climb and i would do it slower again
right so whats a sensible maintenance dose after a year at treatment dose
with a roughly seven day half-life you are near steady state after about five weeks at a dose
*week 20 not week 8
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i drifted from sunday to wednesday over a year and only noticed when i checked the log, still working it out
steady state is 5 weeks
came down from a treatment dose to maintenance over about three months and it was uneventful, i have it written down somewhere
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
quick one i have been at 5 for 11 months and honestly i have stopped wanting to move
you do not have to escalate at all. that is a real option that gets forgotten
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i went from 2.4 to 2 and honestly could not tell the difference in appetite
pick a day and stick to it
has anyone gone up and then straight back down and been glad they tried
anyone tracked whether a smaller more frequent dose changed their side effects
two weeks is nothing
follow up is week 4 too early to be thinking about the next step
sorry to jump in split dosing has no trial behind it. people here do it and report on it, thats all, anyway