while im here if it "stopped working after four days" that is almost never pharmacokinetics, take that with a pinch of salt
#dosing-titration 2025-01-26
Sunday49 messages11 participantstimes are UTC
Highlights from this day
- drawup_dee — if i took it 8 days late do i shift the schedule or go back to the old day 16:09
- noct.titrate — the ladder in the trials is a starting point, not a schedule you owe anyone 17:16
- noct.titrate — sorry to jump in holding is not failing. most people here who lasted two years held at least one dose for months 17:17
- batch_bandit — the honest answer is that most of us are running protocols nobody has ever studied 18:30
how do you decide between holding and stepping when both feel wrong
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, your mileage will differ
if i took it 8 days late do i shift the schedule or go back to the old day
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end of week thing
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no trial for that
you do not have to escalate at all. that is a real option that gets forgotten
my dose day has drifted 8 days later over 9 months, does it matter
do you count from injection day or from when you actually felt it
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
thats noise
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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came down from a treatment dose to maintenance over about three months and it was uneventful
too early imo
the ladder in the trials is a starting point, not a schedule you owe anyone
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sorry to jump in holding is not failing. most people here who lasted two years held at least one dose for months
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
i escalate on symptoms. if the current dose is still doing something i stay on it
is there any actual reason to escalate every 4 weeks other than the trial did it
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
i would hold
pick a day and stick to it
is week 29 too early to be thinking about the next step
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came down, no regrets
anyone tracked whether a smaller more frequent dose changed their side effects
held for months
two weeks is nothing
thats normal
do you tell your prescriber you held or do you just hold
does a missed week reset anything or do you just carry on
update from 2 months ago: held at the same dose the whole time and still losing slowly
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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Reminder set. I will post here in 6 days.
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
the honest answer is that most of us are running protocols nobody has ever studied
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quick one what does the room think about jumping a rung to catch up
do you escalate on the calendar or on how you feel
i went from 1 to 15 and honestly could not tell the difference in appetite
ok so the people who do best here are almost always the ones going slowest
thats anecdote
coming down from 0.5 to 10, how bad is the appetite rebound
genuine question i have been at 2.5 for 5 months and honestly i have stopped wanting to move
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
ok so my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, not advice obviously
has anyone gone up and then straight back down and been glad they tried
how long did you hold at 0.5 before you moved up
how do you tell a plateau from just being at your set point
pick a day and stick to it
i went up too fast and im paying for it, do i drop back or ride it out
whats the longest anyone has stayed on one dose