came down, no regrets
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
do you escalate on the calendar or on how you feel
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
thats noise
Digest for the week of 2024-01-01 has been published.
if i took it 8 days late do i shift the schedule or go back to the old day
small steps are better than big ones and the only reason people take big ones is impatience
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)does a missed week reset anything or do you just carry on
not advice
is it normal for appetite to come back at the end of the week
Inter-lab diff for lot A-2418: 97.4% vs 96.8%. Within expected range.
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i drifted from sunday to wednesday over a year and only noticed when i checked the log
holding is not failing. most people here who lasted two years held at least one dose for months, thats just me
the trials escalated on a fixed schedule because a trial has to. you are not a trial, not advice obviously
appetite returning at the end of the week is extremely common and is not the dose failing
i would hold
stepping back down on purpose is a completely reasonable move and this channel should say so more often
if it "stopped working after four days" that is almost never pharmacokinetics
update from 3 months ago: held at the same dose the whole time and still losing slowly
[edited]is week 25 too early to be thinking about the next step
whats the longest anyone has stayed on one dose
update on the earlier thing my titration ladder took 3 months to climb and i would do it slower again, i have it written down somewhere
anyone tracked whether a smaller more frequent dose changed their side effects
split dosing has no trial behind it. people here do it and report on it, thats all
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step