vialroom

#dosing-titration 2024-05-26

Sunday19 messages4 participantstimes are UTC
Highlights from this day
  • bea_reconstitutes — update from 12 months ago: held at the same dose the whole time and still losing slowly 13:50
  • tenpence — is there any actual reason to escalate every 4 weeks other than the trial did it 15:00
  • slow.taper — my titration ladder took 2 months to climb and i would do it slower again 15:24
TE

if i hold at 2.4 indefinitely am i losing anything

🎉1
BR

update from 12 months ago: held at the same dose the whole time and still losing slowly

Cited study
Effect of Continued Weekly Semaglutide vs Placebo on Weight Loss Maintenance (STEP 4)
JAMA · 2021
The withdrawal arm. This is the trial to read before you plan to stop.
BR

split dosing has no trial behind it. people here do it and report on it, thats all, your mileage will differ

TE

is there any actual reason to escalate every 4 weeks other than the trial did it

📈11

the ladder in the trials is a starting point, not a schedule you owe anyone

has anyone gone up and then straight back down and been glad they tried

TE

with a roughly seven day half-life you are near steady state after about five weeks at a dose

anyone tracked whether a smaller more frequent dose changed their side effects

whats the longest anyone has stayed on one dose

ST

my titration ladder took 2 months to climb and i would do it slower again

Cited study
Semaglutide vs Liraglutide for Weight Loss in Adults with Overweight or Obesity (STEP 8)
JAMA · 2022
Weekly against daily, head to head.
TE

appetite returning at the end of the week is extremely common and is not the dose failing

U1

i have been at 1.7 for 18 months and honestly i have stopped wanting to move

TE

do you escalate on the calendar or on how you feel

ST

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

TE

if it "stopped working after four days" that is almost never pharmacokinetics

ST

update on the earlier thing is there a point where going up stops buying you anything

ok so small steps are better than big ones and the only reason people take big ones is impatience, thats just me