whats your rule for when a side effect means hold rather than push
#dosing-titration 2024-05-25
Saturday15 messages4 participantstimes are UTC
Highlights from this day
- two_four_ceiling — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 17:59
- two_four_ceiling — if i took it 6 days late do i shift the schedule or go back to the old day split dosing has no trial behind it. people here do it and report on it, thats all 18:00
- seven_five_sweet — if it "stopped working after four days" that is almost never pharmacokinetics 18:05
- vial_ledger — coming back to this how long did you hold at 2.4 before you moved up 18:10
the honest answer is that most of us are running protocols nobody has ever studied
i escalate on symptoms. if the current dose is still doing something i stay on it
go slower
whats the longest anyone has stayed on one dose
plateau versus set point is not answerable in under six months of data
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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if i took it 6 days late do i shift the schedule or go back to the old day
split dosing has no trial behind it. people here do it and report on it, thats all
n of 1
if it "stopped working after four days" that is almost never pharmacokinetics
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coming back to this how long did you hold at 2.4 before you moved up
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i would hold
coming back to this you do not have to escalate at all. that is a real option that gets forgotten
18:16chlorhex pinned a message
the trials escalated on a fixed schedule because a trial has to. you are not a trial