if i hold at 10 indefinitely am i losing anything
#dosing-titration 2024-03-10
Sunday16 messages5 participantstimes are UTC
Highlights from this day
- retention_time — appetite returning at the end of the week is extremely common and is not the dose failing 22:22
- retention_time — right so if you are asking whether to go up, the fact you are asking usually means not yet update from 21 months ago: held at the same dose the whole time and still… 22:24
- cold_chain_cmdr — the ladder in the trials is a starting point, not a schedule you owe anyone 22:40
two weeks is nothing
n of 1
the trials escalated on a fixed schedule because a trial has to. you are not a trial
is there a point where going up stops buying you anything
Verification log updated: SWB — evidence added, status unchanged.
i went up too fast and im paying for it, do i drop back or ride it out
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)came down, no regrets
split dosing has no trial behind it. people here do it and report on it, thats all
appetite returning at the end of the week is extremely common and is not the dose failing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
right so if you are asking whether to go up, the fact you are asking usually means not yet
update from 21 months ago: held at the same dose the whole time and still losing slowly
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i escalate on symptoms. if the current dose is still doing something i stay on it
half life is a week
hold
the ladder in the trials is a starting point, not a schedule you owe anyone
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is there a trial anywhere that studied twice weekly, or is it all anecdote